Gustavo Pesce, Ph.D.
Senior Research Fellow
Email: gpesce molsci.org
Tel: 510-981-8701
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Genetically identical yeast cells growing together in homogeneous
cultures respond differently when exposed to pheromone. The
basis for these variations are mostly unknown. To understand
the molecular mechanisms that determine the characteristic
pattern of response of a population of cells to the activation
of the alpha pathway, I developed an approach to identify mutants
that show altered variability in their response to pheromone.
By using fluorescent reporters of the pathway's activity and
of other cell states, I am
characterizing the response to alpha factor in populations of mutant strains.
My objective is to uncover the genetic programming that has evolved to control
the precise output of the pheromone signal transduction cascade.
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